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A novel treatment solution that improves on current therapies in one or more of the following ways: efficacy, safety, skin tolerability, and/or treatment regimen. The ideal approach would be effective for patients with moderate to severe acne. The submitted proposal should include the following: 1.A maximum of 5-10 pages for detailed explanation of the proposed approach 2.A scientific rationale that takes available data into account, preferably including analysis of literature and/or 3.A description of either the patient’s own experience or results from investigator initiated studies THESE ARTICLES MAY HELP YOU! The following articles provide additional information about acne and its treatments. A global perspective on the epidemiology of acne. Tan JK and Bhate K. Br J Dermatol. 2015 July;172 Suppl 1:3-12. [login to view URL] The role of inflammation in the pathology of acne. Tanghetti EA. J Clin Aesthet Dermatol. 2013 September;6(9):27-35. [login to view URL] Diagnosis and treatment of acne. Titus S and Hodge J. Am Fam Physician. 2012 October 15;86(8):734-740. [login to view URL] Acne vulgaris. Williams HC, et. al. Lancet. 2012 January 28;379(9813):361-372. [login to view URL] Guidelines of care for the management of acne vulgaris. Zaenglein AL, et. al. J Am Acad Dermatol. 2016 May;74(5):945-973. [login to view URL](15)02614-6/pdf Acne affects the skin’s oil glands and it is the most common skin disease in the world. It occurs in people of all races and ages, while being highly prevalent in adolescents and young adults. Although acne is not a life threatening condition, severe acne can be quite painful. Having unsightly blemishes causes insecurity and mental distress and cystic acne may develop into disfiguring scarring. Acne develops when the pores of the skin become blocked. These blockages are thought to occur as a result of the following four abnormal processes: a higher than normal amount of sebum production, excessive deposition of the protein keratin leading to comedone formation, colonization of the follicle by Propionibacterium acnes (P. acnes) bacteria, and the local release of pro-inflammatory chemicals in the skin. Certain triggers such as hormonal changes, certain medications, and heredity have been identified, but flare-ups of the condition are typical, yet unpredictable.