writing literature review

writing literature review about this following topic: Evaluation of Interleukin-17 Level in ActiveAntiviral Treated Human Immunodeficiency in Virus It is now well recognized that, in the majority of cases, the developmentof AIDS parallels the decline in CD4+ T cells, which play a vital role inthe regulation of the immune response. The monitoring of CD4+ T cellsduring the course of HIV infection is therefore a crucial component inthe monitoring of disease progression and the response to antiviraltherapy. Other T cell subsets may also be contributing to IL-17production in vivo, and these cells may be important during HIVpathogenesis. Interleukin (IL)-17 is produced mainly by activated CD4+T cell, currently known as [login to view URL] markers,such as viral load and CD4+ cell count, are regularly used for patientmanagement in addition to predicting disease progression and/ortreatment [login to view URL] IL-17 is produced mainly by activated CD4+ T cell, currently known as Th17. Plasma IL-17 levels are significantlydecreased in HIV/AIDS patients compared to controls before [login to view URL] therapy cause significant increases in the IL-17 level 6 or 12 months after [login to view URL] another study; they found imbalance between Th17 cells and Tregcells in the peripheral blood of HIV/AIDS patients, suggesting that theimbalance of Treg cells and Th17 cells plays an important role inHIV/AIDS pathogenesis as well as a significant loss of CD4+ T [login to view URL] active antiretroviral therapy helped to restore the Th17/Tregbalance as well as IL-17 level in the patients. The balance of Th17/Tregcould be a target for the development of new therapeutic strategies andvaccines for HIV/AIDS treatment [10]. It was dynamically observed forthe changes in peripheral blood Th17, Treg cells, and interleukin (IL)-17 levels in HIV-1/AIDS patients before and after highly activeantiretroviral therapy (HAART). THE AIMS OF THE RESEARC OBJECTIVES In order to determine the significant role of IL-17-producing CD4+ and another cytokines; the studied samples for HIV adults patient range from 20-50 years [login to view URL] addition to control group (healthy persons) Objectives of this study aimed to: 1. Infection with HIV results in dysregulation of the cytokine profilein vivo and in vitro. For example interleukin(IL)-2, and antiviral interferon (IFN)-γ, is generally decreased,whereas production of T helper type 2 (Th2) cytokines, IL-4, IL-10, proinflammatory cytokines (IL-1, IL-6, IL-8 and tumournecrosis factor (TNF)-α, is increased. Such abnormal cytokineproduction contributes to the pathogenesis of the disease byimpairing cell mediated [login to view URL] we will evaluate the significant effect of IL-17 (IL-17A and IL-17F) in case of AIDS cohort [login to view URL] addition other cytokines (IL2,IL-4,IL-6,IL-10,IL-21,IL-22,IL-27, IL-33, INFγ,TNFα). 2. Follow up of IL-17 , Th1 (IFN-γ) , Th2 (IL-4,IL-10) andproinflammatory IL-6 and another cytokines during treatment (HARRT 1)and repeated after 2-6months (HAART2)for the evaluation the antiviral drug efficiency. The effectof cytokines on HIV-1 can be either inhibitory, stimulatory [login to view URL] patients were scheduled to visit the clinicroutinely. 3. Correlation between IL-17 with other cytokines and immunephenotypingof lymphocytes subsets and viral load in case patients (HAART 1 and HAART 2) and control. In addition the Correlation between IL-17 with other cytokines and immunephenotyping of lymphocytes subsets and viral load and PRA (PRA is screening test of IgG antibodies class I and classII ) in case patients and control.